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There is no pharmacokinetic evidence showing that smoking directly reduces tirzepatides effectiveness in the body

If you find that after switching to Wegovy, your side effects are worse than they were on Mounjaro, speak to your clinician, as you may need to return to Mounjaro or try a different treatment altogether

Another review listed a study that followed 1022 patients with breast cancer, 389 of whom took a GLP-1R agonist for up to 12 months, which resulted in up to 3.1% weight loss

Most are simply noticing that the mental sharpness they used to take for granted has quietly slipped